OMERO Plus automatically ingests plate image and metadata from Revvity’s Opera Phenix, Molecular Devices’ ImageXpress, and Thermo Fisher Scientific’s Cellomics

In the domain of High Content Screening, acquisition systems are often associated with a database to manage both image data and metadata. Because this data management is specific to the vendor’s particular acquisition system and often is isolated per-system (not cross-system for multiple instruments), Glencoe Software customers often prefer that this data be imported into OMERO Plus for improved interoperability with other imaging experiments. Unfortunately, export from the vendor’s database for import into OMERO Plus can be a time consuming and manual process.

Now, Glencoe Software has added direct database integration support for three popular High Content Screening systems: Revvity’s Opera Phenix (see the latest on the sunset of Columbus support here), Molecular Devices’ ImageXpress, and Thermo Fisher Scientific’s Cellomics.

How it works

Glencoe’s Bio-Formats (or similar tooling in cases where direct Bio-Formats support has not been viable) directly queries the acquisition database for information on the image file location(s) and relevant acquisition metadata. The output of this query is written to a metadata file, which can then be used as the input to an OMERO import.

For those working in the cloud, plate data can be converted to OME-Zarr prior to import into OMERO Plus from S3 object storage.

These processes can be run on a schedule for fully automated integration between your HCS systems and OMERO Plus.

These improvements in Bio-Formats and OMERO Plus make the ingestion and management of High Content Screening data more seamless and interoperable than ever before. Please reach out to Glencoe Software to get started today by contacting info@glencoesoftware.com.